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Reactions of alpha -amino nitriles. 10. Synthesis of 1-amino-1-aryl-2-alkynes with cholinergic and cholinolytic properties

Thies, Heinrich and Schönenberger, Helmut and El-Zanaty, M. (1972) Reactions of alpha -amino nitriles. 10. Synthesis of 1-amino-1-aryl-2-alkynes with cholinergic and cholinolytic properties. Arzneimittel-Forschung = Drug research 22 (7), pp. 1138-1144.

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Abstract

Thirty-two RR1NCHR2C==CR3 [R = R1 = Me, Et, NRR1 = 1-pyrrolidinyl, piperidino, morpholino, R2 = 3,4-(MeO)2C6H3, Ph, m-HOC6H4, p-ClC6H4, o-MeOC6H4, p-MeOC6H4, 3,4-HO(MeO)C6H3, 3,4-(methylenedioxy)phenyl, R3 = Pr, Bu, pentyl, Ph, H] and/or their picrates or hydrochlorides were prepd. (37-88%) by the reaction of RR1NCHR2CN and ...

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Item Type:Article
Date:1972
Additional information (public):CAN 77:151836 27-17 Heterocyclic Compounds (One Hetero Atom) 5097-99-4P; 15190-13-3P; 31466-31-6P; 36057-68-8P; 36057-69-9P; 36057-77-9P; 36057-78-0P; 36057-81-5P; 37672-94-9P; 37672-95-0P; 37672-96-1P; 37672-97-2P; 37672-99-4P; 37673-00-0P; 37673-01-1P; 37673-03-3P; 37673-04-4P; 37673-05-5P; 37673-06-6P; 37673-07-7P; 37673-08-8P; 37673-10-2P; 37673-11-3P; 37679-18-8P; 37679-19-9P; 37679-20-2P; 37679-21-3P; 37679-22-4P; 37679-23-5P; 37679-25-7P; 37679-27-9P; 37679-28-0P; 37679-29-1P; 37679-30-4P; 37679-31-5P; 37679-32-6P; 37679-33-7P; 37679-34-8P; 37679-36-0P; 37679-37-1P; 37679-38-2P; 37679-39-3P; 37679-40-6P; 37679-41-7P; 37679-42-8P; 37679-43-9P; 37679-44-0P; 37679-45-1P; 37679-46-2P; 37679-47-3P; 37679-48-4P; 37679-49-5P; 37679-50-8P; 37679-51-9P; 37679-53-1P; 37679-55-3P; 37679-56-4P; 37679-57-5P; 37679-58-6P; 37679-59-7P; 37679-60-0P; 37679-61-1P; 37679-62-2P; 37739-06-3P; 37739-07-4P; 37826-86-1P; 37829-37-1P; 37835-09-9P Role: SPN (Synthetic preparation), PREP (Preparation) (prepn. of)
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Retired Professors > Prof. Schönenberger
Identification Number:
ValueType
1972:551836Other
Keywords:Nitriles Role: RCT (Reactant), RACT (Reactant or reagent) (alpha -amino) aminonitrile reaction alkyne Grignard arylalkyne amino nitrile amino reaction alkyne
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Petra Gürster
Deposited On:19 Nov 2010 06:27
Last Modified:19 Nov 2010 06:27
Item ID:18206
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