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Expression and functional properties of canine, rat and murine histamine H4-receptors in Sf9 insect cells

Schnell, David and Brunskole, Irena and Ladova, Katerina and Schneider, Erich H. and Igel, Patrick and Dove, Stefan and Buschauer, Armin and Seifert, Roland (2011) Expression and functional properties of canine, rat and murine histamine H4-receptors in Sf9 insect cells. Naunyn-Schmiedeberg's Archives of Pharmacology 383 (5), pp. 457-470.

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Other URL: http://www.springerlink.com/content/p3u17q42n1802256/, http://www.springerlink.com/content/p3u17q42n1802256/fulltext.pdf


Abstract

The histamine H4-receptor (H4R) is expressed on cells of the immune system including eosinophils, dendritic cells and T cells and plays an important role in the pathogenesis of bronchial asthma, atopic dermatitis and pruritus. Analysis of the H4R in these diseases depends on the use of animal models. However, there are substantial pharmacological differences between various H4R species orthologs. ...

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Item Type:Article
Date:26 February 2011
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1007/s00210-011-0612-3DOI
21359967PubMed ID
UNSPECIFIEDOther
Keywords:histamine H4-receptor, histamine, receptor species orthologs, JNJ7777120, GTPase, Sf9 insect cells
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:15 Dec 2010 12:32
Last Modified:30 Apr 2011 14:41
Item ID:18359
Owner Only: item control page
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