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Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor.

Silva, Maria Elena and Heim, Ralf and Strasser, Andrea and Elz, Sigurd and Dove, Stefan (2011) Theoretical studies on the interaction of partial agonists with the 5-HT(2A) receptor. Journal of computer-aided molecular design 25 (1), pp. 51-66.

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Abstract

A series of 51 5-HT(2A) partial agonistic arylethylamines (primary or benzylamines) from different structural classes (indoles, methoxybenzenes, quinazolinediones) was investigated by fragment regression analysis (FRA), docking and 3D-QSAR approaches. The data, pEC(50) values and intrinsic activities (E(max)) on rat arteries, show high variability of pEC(50) from 4 to 10 and of E(max) from 15 to ...

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Item Type:Article
Date:18 January 2011
Additional information (public):bisher online veröffentlicht
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Research groups and research centres:Not selected
Identification Number:
ValueType
21088982PubMed ID
10.1007/s10822-010-9400-2DOI
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Dr. Stefan Dove
Deposited On:26 Nov 2010 06:36
Last Modified:31 Jan 2011 14:50
Item ID:18438
Owner Only: item control page
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