Anreicherung der Enantiomeren, Circulardichroismus und absolute Konfiguration von N,N,N′,N′-Tetramethyldithiooxamid

Abstract

(+)- and (–)-1 (N,N,Nprime,Nprime-Tetramethyldithiooxamide) were enriched by semipreparative liquid chromatography on triacetylcellulose. According to1HNMR in the presence of an optically active auxiliary, the sample of (+)365-1 had an enantiomeric purity of 0,50±0,01, thus permitting to calculate the CD spectrum for the pure enantiomer. The CD and UV spectra are discussed in terms of qualitative MO theory. Thereby, the absolute configuration of (+)365-1 is determined to be (R).