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Differential potency of atropisomers of polychlorinated biphenyls on cytochrome P450 induction and uroporphyrin accumulation in the chick embryo hepatocyte culture

Rodman, L. E. and Shedlofsky, S. I. and Mannschreck, Albrecht and Püttmann, Michael and Swim, A. T. and Robertson, L. W. (1991) Differential potency of atropisomers of polychlorinated biphenyls on cytochrome P450 induction and uroporphyrin accumulation in the chick embryo hepatocyte culture. Biochemical pharmacology 41 (6-7), pp. 915-922.

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Abstract

The atropisomers of 2,2',3,4,6-pentachlorobiphenyl (PeCB), 2,2',3,4,4',6-hexachlorobiphenyl (HeCB), and 2,2',3,3',4,4',6,6'-octachlorobiphenyl (OCB) were studied in the chick embryo hepatocyte culture to determine if chirality plays a role in the recognition events associated with the induction of cytochromes P450 and the accumulation of uroporphyrin (URO). Concentration-related induction of ...

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Item Type:Article
Date:1991
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Retired Professors > Prof.Dr. Mannschreck
Identification Number:
ValueType
10.1016/0006-2952(91)90196-CDOI
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:02 Dec 2010 09:31
Last Modified:02 Dec 2010 09:32
Item ID:18535
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