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Erythroid pyrimidine 5'-nucleotidase: cloning, developmental expression, and regulation by cAMP and in vivo hypoxia

Mass, Markus and Simo, Erika and Dragon, Stefanie (2003) Erythroid pyrimidine 5'-nucleotidase: cloning, developmental expression, and regulation by cAMP and in vivo hypoxia. Blood 102 (12), pp. 4198-4205.

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Abstract

A characteristic process of terminal erythroid differentiation is the degradation of ribosomal RNA into mononucleotides. The pyrimidine mononucleotides can be dephosphorylated by pyrimidine 5'-nucleotidase (P5N-I). In humans, a lack of this enzyme causes hemolytic anemia with ribosomal structures and trinucleotides retained in the red blood cells (RBCs). Although the protein/nucleotide sequence ...

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Item Type:Article
Date:2003
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Rosemarie Baumann
Identification Number:
ValueType
12907448PubMed ID
10.1182/blood-2002-11-3388DOI
Classification:
NotationType
2,3-Diphosphoglycerate/metabolismMESH
5'-Nucleotidase/metabolismMESH
Adenosine/pharmacologyMESH
AnimalsMESH
Anoxia/enzymologyMESH
Base SequenceMESH
Carbonic Anhydrase II/biosynthesisMESH
Cell DifferentiationMESH
Chick EmbryoMESH
Cloning, MolecularMESH
Cyclic AMP/pharmacologyMESH
Erythrocyte AgingMESH
Erythrocytes/enzymologyMESH
Gene Expression ProfilingMESH
Gene Expression Regulation, Developmental/drug effectsMESH
Molecular Sequence DataMESH
Norepinephrine/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:09 Dec 2010 06:56
Last Modified:09 Dec 2010 06:56
Item ID:18626
Owner Only: item control page
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