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Regulation von Proteinen des Proteasoms, Immunproteasoms bei der Differenzierung von intestinalen Makrophagen

URN to cite this document: urn:nbn:de:bvb:355-epub-186903

Seidl, Monika Christine (2010) Regulation von Proteinen des Proteasoms, Immunproteasoms bei der Differenzierung von intestinalen Makrophagen. PhD, Universität Regensburg

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Abstract (German)

Das Proteasom stellt einen multikatalytischen Enzymkomplex dar, der den Hauptanteil der Proteindegradation einer Zelle leistet. Es spaltet Proteine, die dann auf dem MHC-I-Komplex präsentiert werden und trägt entscheidend zur B- und T-Zell-Aktivierung bei. Affymetrix-GeneChip®-Analysen aus früheren Untersuchungen der Arbeitsgruppe haben gezeigt, dass IMACs im Gegensatz zu in vitro ...


Translation of the abstract (English)

The Proteasome is a multicatalytic enzyme complex, which is responsible for the main part of protein degradation. It splits proteins, which are presented on class I MHC molecules and it is important for the activation of B- and T-cells. Affymetrix GeneChip analysis showed that IMACs, contrary to i.v. MACs, possess an anergic phenotype with a downregulation of mRNA expression of almost all ...


Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:17 December 2010
Referee:PD Dr. Esther Endlicher and PD Dr. Stefan Farkas
Date of exam:8 December 2010
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Interdisciplinary Subject Network:Not selected
Keywords:Morbus Crohn, Colitis ulcerosa, Proteasom, Makrophagen, IMAC, CED
Subjects:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited On:17 Dec 2010 16:24
Last Modified:13 Mar 2014 14:15
Item ID:18690
Owner Only: item control page


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