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High-frequency 94 GHz ENDOR characterization of the metal binding site in wild type Ras. GDP and its oncogenic mutant G12V in frozen solution

Bennati, M. and Hertel, M. and Fritscher, J. and Prisner, T. and Weiden, N. and Hofweber, R. and Spörner, M. and Horn, G. and Kalbitzer, Hans-Robert (2006) High-frequency 94 GHz ENDOR characterization of the metal binding site in wild type Ras. GDP and its oncogenic mutant G12V in frozen solution. Biochemistry 45 (1), pp. 42-45.

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Abstract

The guanine nucleotide binding protein Ras plays a central role as molecular switch in cellular signal transduction. Ras cycles between a GDP-bound "off" state and a GTP-bound "on" state. Specific oncogenic mutations in the Ras protein are found in up to 30% of all human tumors. Previous 31P NMR studies had demonstrated that in liquid solution different conformational states in the GDP-bound as ...

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Item Type:Article
Date:2006
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Projects:Graduiertenkolleg Nichtlinearität und Nichtgleichgewicht
Identification Number:
ValueType
10.1021/bi051156k S0006-2960(05)01156-6DOI
Subjects:500 Science > 530 Physics
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Redakteur Physik
Deposited On:20 Mar 2007
Last Modified:13 Mar 2014 10:08
Item ID:1882
Owner Only: item control page
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