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Observation of intermediate states of the human prion protein by high pressure NMR spectroscopy

Kachel, Norman and Kremer, Werner and Zahn, Ralph and Kalbitzer, Hans-Robert (2006) Observation of intermediate states of the human prion protein by high pressure NMR spectroscopy. BMC Structural Biology 6 (16).

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Abstract

Background Prions as causative agents of transmissible spongiform encephalopathies (TSEs) in humans and animals are composed of the infectious isomer, PrPSc, of the cellular prion protein, PrPC. The conversion and thus the propensity of PrPC to adopt alternative folds leads to the species-specific propagation of the disease. High pressure is a powerful tool to study the physico-chemical ...

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Item Type:Article
Date:2006
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Projects:Graduiertenkolleg Nichtlinearität und Nichtgleichgewicht
Identification Number:
ValueType
10.1186/1472-6807-6-16DOI
Subjects:500 Science > 530 Physics
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Redakteur Physik
Deposited On:20 Mar 2007
Last Modified:13 Mar 2014 10:08
Item ID:1886
Owner Only: item control page

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