Go to content
UR Home

Antigen specific recognition is critical for the function of regulatory CD8+ CD28- T cells

URN to cite this document: urn:nbn:de:bvb:355-epub-190277

Renner, Philipp (2011) Antigen specific recognition is critical for the function of regulatory CD8+ CD28- T cells. PhD, Universität Regensburg.

License: Publishing license for publications excluding print on demand
Download (861kB)

Abstract (English)

The immunomodulatory properties of CD8 T cells with regulatory phenotype have become evident. It remains unclear whether the immunomodulatory function of CD8+ CD28- T cells requires antigen-specific TCR interaction with major histocompatibility complex class I (MHC-I). We have isolated naïve CD8+CD28- T suppressor cells (Tsup) from H2-Kk Des-TCR mice that express a transgenic, MHC class ...


Translation of the abstract (German)

Als Teil des erworbenen Immunsystems spielen T-Zellen eine wichtige Rolle in der Bekämpfung von Krankheitserregern, indem sie körperfremdes Antigen erkennen und so eine Immunantwort verursachen. Allerdings existieren nicht nur T-Zellen, die Immunantworten induzieren und unterhalten, sondern auch solche, die eine Immunreaktion verhindern bzw. beenden. Diese Zellpopulationen sind Gegenstand vieler ...


Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:17 January 2011
Referee:PD Dr. Marc-Hendrik Dahlke and Prof. Dr. Bernhard Banas
Date of exam:10 January 2011
Institutions:Medicine > Lehrstuhl für Chirurgie
Interdisciplinary Subject Network:Not selected
Keywords:CD8, CD28, T suppressor cells, T regulatory cells, TCR, MHC class-I, antigen recognition
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Deposited On:17 Jan 2011 11:10
Last Modified:13 Mar 2014 16:47
Item ID:19027
Owner Only: item control page


Downloads per month over past year

  1. Homepage UR

University Library

Publication Server

Contact person
Gernot Deinzer

Phone +49 941 943-2759