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Characterization and functional analysis of the transfer of cell components from human antigen-presenting cells onto T cells via antigen-specific trogocytosis

URN to cite this document: urn:nbn:de:bvb:355-epub-190665

Gary, Regina (2011) Characterization and functional analysis of the transfer of cell components from human antigen-presenting cells onto T cells via antigen-specific trogocytosis. PhD, Universität Regensburg

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Abstract (English)

Specific T-cell responses are initiated by TCR recognition of pMHC-complexes on APC. Upon specific interaction of T cells with APC, T cells capture membrane fragments and surface molecules in a process termed trogocytosis. Exchange of membrane molecules/antigens between immune cells has been observed for a long time, but the mechanisms and functional consequences of these transfers remain ...

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Translation of the abstract (German)

Spezifische T-Zell-Antworten werden über die Erkennung von Peptid-MHC-Komplexen auf Antigen-präsentierenden Zellen (APC) durch T-Zell-Rezeptoren (TCR) initiiert. Nach antigen-spezifischer Interaktion von T-Zellen mit APC können T-Zellen sowohl Membranfragmente als auch Oberflächenmoleküle von APC akquirieren, ein Vorgang, der als Trogozytose definiert wird. Der Austausch von Membranmolekülen und ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:7 February 2011
Referee:Prof. Dr. Andreas Mackensen and Prof. Dr. Susanne Modrow
Date of exam:17 January 2011
Institutions:Medicine > Abteilung für Hämatologie und Internistische Onkologie
Biology, Preclinical Medicine
Research groups and research centres:Not selected
Keywords:Trogocytosis, antigen-specific transfer, human T cells, PD-L1, DC-SIGN
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:07 Feb 2011 12:44
Last Modified:13 Mar 2014 16:48
Item ID:19066
Owner Only: item control page
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