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Paradoxical stimulatory effects of the “standard” histamine H4-receptor antagonist JNJ7777120: The H4-receptor joins the club of 7TM receptors exhibiting functional selectivity

Seifert, Roland and Schneider, Erich H. and Dove, Stefan and Brunskole, Irena and Neumann, Detlef and Strasser, Andrea and Buschauer, Armin (2011) Paradoxical stimulatory effects of the “standard” histamine H4-receptor antagonist JNJ7777120: The H4-receptor joins the club of 7TM receptors exhibiting functional selectivity. Molecular Pharmacology 79 (4), pp. 631-638.

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Abstract

The histamine H4-receptor (H4R) is expressed in several cell types of the immune system and is assumed to play an important pro-inflammatory role in various diseases including bronchial asthma, atopic dermatitis and pruritus. Accordingly, H4R antagonists have been suggested to provide valuable drugs for the treatment of the afore-mentioned diseases. Over the past decade, the indole derivative, ...

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Item Type:Article
Date:25 January 2011
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1124/mol.111.071266DOI
21266488PubMed ID
Related URLs:
URLURL Type
http://molpharm.aspetjournals.org/content/early/2011/01/25/mol.111.071266.abstractPublisher
Keywords:Histamine; Gi protein family; G protein regulation; GRKs; beta-arrestins; Phosphorylation; Dephosphorylatin; Structure-activity relationships; Molecular modeling * Receptor binding studies
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Owner: Prof. Armin Buschauer
Deposited On:26 Jan 2011 12:03
Last Modified:08 Jan 2013 09:22
Item ID:19113
Owner Only: item control page
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