A novel drug-eluting stent coated with an integrin-binding cyclic Arg-Gly-Asp peptide inhibits neointimal hyperplasia by recruiting endothelial progenitor cells

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.1940

Blindt, Rüdiger ; Vogt, Felix ; Astafieva, Irina ; Fach, Christian ; Hristov, Mihail ; Krott, Nicole ; Seitz, Berthold ; Kapurniotu, Aphrodite ; Kwok, Connie ; Dewor, Manfred ; Bosserhoff, Anja-Katrin ; Bernhagen, Jürgen ; Hanrath, Peter ; Hoffmann, Rainer ; Weber, Christian

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Veröffentlichungsdatum dieses Volltextes: 05 Aug 2009 13:35

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OBJECTIVES: Novel stents loaded with an integrin-binding cyclic Arg-Gly-Asp peptide (cRGD) were analyzed for their potential to limit coronary neointima formation and to accelerate endothelialization by attracting endothelial progenitor cells (EPCs). BACKGROUND: Re-endothelialization is important for healing after arterial injury. METHODS: Effects of cRGD on EPC number, recruitment in flow, and ...