Catto, James W. F. and Hartmann, Arndt and Stoehr, Robert and Bolderson, Emma and Rehman, Ishtiaq and Rosario, Derek J. and Hamdy, Freddie C. and Meuth, Mark (2006) Multifocal urothelial cancers with the mutator phenotype are of monoclonal origin and require panurothelial treatment for tumor clearance. The Journal of urology 175 (6), pp. 2323-2330.
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PURPOSE: UC is a disease of the entire urothelium, characterized by multiplicity and multifocality. The clonal relationship among multiple UCs has implications regarding adjuvant chemotherapy. It has been investigated in studies of chromosomal alteration and single gene mutation. However, these genetic changes can occur in unrelated tumors under similar carcinogenic selection pressures. Tumors ...
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|Institutions:||Medicine > Lehrstuhl für Pathologie|
|Keywords:||bladder; bladder neoplasms; urothelium; microsatellite repeats; methylation|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||29 Mar 2007|
|Last Modified:||13 Mar 2014 10:10|