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Multifocal urothelial cancers with the mutator phenotype are of monoclonal origin and require panurothelial treatment for tumor clearance

Catto, James W. F. and Hartmann, Arndt and Stoehr, Robert and Bolderson, Emma and Rehman, Ishtiaq and Rosario, Derek J. and Hamdy, Freddie C. and Meuth, Mark (2006) Multifocal urothelial cancers with the mutator phenotype are of monoclonal origin and require panurothelial treatment for tumor clearance. The Journal of urology 175 (6), pp. 2323-2330.

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Other URL: http://dx.doi.org/10.1016/S0022-5347(06)00256-4


Abstract

PURPOSE: UC is a disease of the entire urothelium, characterized by multiplicity and multifocality. The clonal relationship among multiple UCs has implications regarding adjuvant chemotherapy. It has been investigated in studies of chromosomal alteration and single gene mutation. However, these genetic changes can occur in unrelated tumors under similar carcinogenic selection pressures. Tumors ...

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Item Type:Article
Date:June 2006
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
16697867PubMed ID
10.1016/S0022-5347(06)00256-4DOI
Keywords:bladder; bladder neoplasms; urothelium; microsatellite repeats; methylation
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Ute Lange
Deposited On:29 Mar 2007
Last Modified:13 Mar 2014 10:10
Item ID:1942
Owner Only: item control page

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