Thasler, Wolfgang E. and Dayoub, Rania and Mühlbauer, Marcus and Hellerbrand, Claus and Singer, Thomas and Gräbe, Anja and Jauch, Karl-Walter and Schlitt, Hans-Jürgen and Weiss, Thomas S. (2006) Repression of cytochrome P450 activity in human hepatocytes in vitro by a novel hepatotrophic factor, augmenter of liver regeneration. The Journal of pharmacology and experimental therapeutics 316 (2), pp. 822-829.
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Other URL: http://dx.doi.org/10.1124/jpet.105.094201
Pathological disorders of the liver were shown to be associated with an impairment of hepatic drug metabolism mediated in part by growth factors. Augmenter of liver regeneration (ALR) is a novel liver-specific hepatotrophic growth factor, whereas its action on cytochrome P450 (P450) metabolism is completely unknown. Application of ALR to primary human hepatocytes in vitro reduced P450 isoenzyme ...
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|Institutions:||Medicine > Lehrstuhl für Innere Medizin I|
Medicine > Lehrstuhl für Chirurgie
|Subjects:||500 Science > 570 Life sciences|
600 Technology > 610 Medical sciences Medicine
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||23 Apr 2007|
|Last Modified:||13 Mar 2014 10:11|