Startseite UB

Repression of cytochrome P450 activity in human hepatocytes in vitro by a novel hepatotrophic factor, augmenter of liver regeneration

Thasler, Wolfgang E. and Dayoub, Rania and Mühlbauer, Marcus and Hellerbrand, Claus and Singer, Thomas and Gräbe, Anja and Jauch, Karl-Walter and Schlitt, Hans-Jürgen and Weiss, Thomas S. (2006) Repression of cytochrome P450 activity in human hepatocytes in vitro by a novel hepatotrophic factor, augmenter of liver regeneration. The Journal of pharmacology and experimental therapeutics 316 (2), pp. 822-829.

[img]PDF
Download (303kB) - Repository staff only

at PubMed

at publisher (via DOI)

Other URL: http://dx.doi.org/10.1124/jpet.105.094201


Abstract

Pathological disorders of the liver were shown to be associated with an impairment of hepatic drug metabolism mediated in part by growth factors. Augmenter of liver regeneration (ALR) is a novel liver-specific hepatotrophic growth factor, whereas its action on cytochrome P450 (P450) metabolism is completely unknown. Application of ALR to primary human hepatocytes in vitro reduced P450 isoenzyme ...

plus


Export bibliographical data



Item Type:Article
Date:February 2006
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Medicine > Lehrstuhl für Chirurgie
Identification Number:
ValueType
16214878PubMed ID
10.1124/jpet.105.094201DOI
Subjects:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Ute Lange
Deposited On:23 Apr 2007
Last Modified:13 Mar 2014 10:11
Item ID:1959
Owner Only: item control page

Downloads

Downloads per month over past year

  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact