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Different proliferative and survival capacity of CLL-cells in a newly established in vitro model for pseudofollicles.

Plander, M and Seegers, Silvia and Ugocsai, P and Diermeier-Daucher, S and Iványi, J and Schmitz, G and Hofstädter, F and Schwarz, S and Orsó, E and Knüchel, R and Brockhoff, G (2009) Different proliferative and survival capacity of CLL-cells in a newly established in vitro model for pseudofollicles. Leukemia 23 (11), pp. 2118-2128.

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Other URL: http://www.nature.com/leu/journal/v23/n11/full/leu2009145a.html


Abstract

Chronic lymphocytic leukemia (CLL) is a malignancy of mature B-lymphocytes that manifests in a variety of clinical courses. The accumulation of CLL-cells is primarily caused by defective apoptosis; however, a higher proliferative capacity has also been found to correlate with poorer prognostic factors. Proliferating CLL-cells are confined to specialized structures called pseudofollicles, which ...

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Item Type:Article
Date:6 August 2009
Institutions:Medicine > Lehrstuhl für Pathologie
Identification Number:
ValueType
19657365PubMed ID
10.1038/leu.2009.145DOI
Classification:
NotationType
AdultMESH
AgedMESH
Aged, 80 and overMESH
Anemia/pathologyMESH
Apoptosis/physiologyMESH
Bone Marrow/pathologyMESH
CD40 Ligand/pharmacologyMESH
Cell Culture Techniques/methodsMESH
Cell Differentiation/physiologyMESH
Cell Division/physiologyMESH
Cell Survival/physiologyMESH
Culture Media/pharmacologyMESH
FemaleMESH
HumansMESH
ImmunophenotypingMESH
Interleukin-10/pharmacologyMESH
Interleukin-2/pharmacologyMESH
Interleukin-4/pharmacologyMESH
Leukemia, Lymphocytic, Chronic, B-Cell/pathologyMESH
MaleMESH
Middle AgedMESH
PrognosisMESH
Stromal Cells/cytologyMESH
Thrombocytopenia/pathologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Silvia Seegers
Deposited On:14 Feb 2011 12:43
Last Modified:13 Mar 2014 16:53
Item ID:19599
Owner Only: item control page
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