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Reduced responsiveness of adenylate cyclase to forskolin in human lymphoma cells

Hallek, M. and Kampfrath, T. and Haen, Ekkehard and Göhly, U. and Emmerich, B. and Remien, J. (1991) Reduced responsiveness of adenylate cyclase to forskolin in human lymphoma cells. Biochemical pharmacology 42 (7), pp. 1329-1334.

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Abstract

The beta 2-adrenergic transmembrane signal transduction was investigated in malignant B-cells from 15 patients with low grade non-Hodgkin's lymphoma as compared with normal lymphocytes of seven healthy adults. The number of beta 2-adrenoceptors and the response of adenylate cyclase (AC) to isoproterenol were slightly decreased in lymphoma cells. The responsiveness of AC to forskolin was 8-fold ...

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Item Type:Article
Date:1991
Institutions:Medicine > Lehrstuhl für Psychiatrie und Psychotherapie
Identification Number:
ValueType
1656984PubMed ID
10.1016/0006-2952(91)90442-8DOI
Classification:
NotationType
Adenylate Cyclase/antagonists & inhibitorsMESH
AgedMESH
B-Lymphocytes/enzymologyMESH
Binding SitesMESH
Cholera Toxin/pharmacologyMESH
Cyclic AMP/metabolismMESH
FemaleMESH
Forskolin/pharmacologyMESH
HumansMESH
Isoproterenol/pharmacologyMESH
Lymphoma, Non-Hodgkin/enzymologyMESH
MaleMESH
Middle AgedMESH
Pindolol/pharmacologyMESH
Receptors, Adrenergic, beta/drug effectsMESH
Signal Transduction/drug effectsMESH
Tumor Cells, Cultured/drug effectsMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:18 Feb 2011 10:22
Last Modified:13 Mar 2014 16:53
Item ID:19636
Owner Only: item control page

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