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Effect of thiols on beta 2-adrenoceptors in human mononuclear leucocytes

Liebl, B. and Anhäupl, T. and Haen, Ekkehard and Remien, J. (1988) Effect of thiols on beta 2-adrenoceptors in human mononuclear leucocytes. Naunyn-Schmiedeberg's archives of pharmacology 338 (5), pp. 523-528.

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Abstract

The effect of the disulfide reducing agent dithiothreitol (DTT) and other thiols on binding of the beta-adrenoceptor antagonist (-)-125iodocyanopindolol (125ICYP) to human mononuclear leucocytes (MNL) was investigated. Saturation experiments and dissociation kinetics revealed two classes of specific 125ICYP binding sites, one of high and the other of low affinity, respectively. In intact MNL DTT ...

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Item Type:Article
Date:1988
Institutions:Medicine > Lehrstuhl für Psychiatrie und Psychotherapie
Identification Number:
ValueType
2854211PubMed ID
Classification:
NotationType
Cell Membrane/physiologyMESH
Cyclic AMP/analysisMESH
Dose-Response Relationship, DrugMESH
HumansMESH
IodocyanopindololMESH
Lymphocytes/ultrastructureMESH
Pindolol/pharmacokineticsMESH
Receptors, Adrenergic, beta/drug effectsMESH
Sulfhydryl Compounds/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:18 Feb 2011 10:27
Last Modified:13 Mar 2014 16:54
Item ID:19642
Owner Only: item control page

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