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Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells

Roesch, Alexander and Becker, Bernd and Schneider-Brachert, Wulf and Hagen, Ilja and Landthaler, Michael and Vogt, Thomas (2006) Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells. The Journal of investigative dermatology 126 (8), pp. 1850-1859.

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Other URL: http://dx.doi.org/10.1038/sj.jid.5700324


Abstract

The loss of cell cycle control in malignant melanomas is thought to be due to a lack of retinoblastoma protein (pRb) activity. We have recently reported a progressive deficiency of the retinoblastoma-binding protein 2-homolog 1 (RBP2-H1) in advanced and metastatic melanomas in vivo, suggesting a role of RBP2-H1 in loss of pRb-mediated control. Therefore, in this study, we re-established the ...

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Item Type:Article
Date:August 2006
Institutions:Medicine > Lehrstuhl für Dermatologie und Venerologie
Identification Number:
ValueType
16645588PubMed ID
10.1038/sj.jid.5700324DOI
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Ute Lange
Deposited On:30 Mar 2007
Last Modified:13 Mar 2014 10:11
Item ID:1966
Owner Only: item control page

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