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Comparative bioavailability of the microemulsion formulation of cyclosporine (Neoral) with a generic dispersion formulation (Cicloral) in young healthy male volunteers

Kees, Frieder and Bucher, Michael and Schweda, Frank and Gschaidmeier, Harald and Burhenne, Juergen and Mikus, Gerd and Faerber, Lothar (2006) Comparative bioavailability of the microemulsion formulation of cyclosporine (Neoral) with a generic dispersion formulation (Cicloral) in young healthy male volunteers. Therapeutic drug monitoring 28 (3), pp. 312-320.

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Other URL: http://dx.doi.org/10.1097/01.ftd.0000211804.89440.74


Abstract

The aim of this study was to compare the bioavailability of cyclosporine (CyA) from the generic dispersion formulation Cicloral (CIC) with the microemulsion formulation Neoral (NEO) and the original Sandimmune (SIM) capsules after single doses of 100, 300, or 600 mg of drug, respectively. The study was performed according to an open 3-period cross-over design with 12 young healthy male volunteers ...

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Item Type:Article
Date:June 2006
Institutions:Medicine > Lehrstuhl für Anästhesiologie
Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
10.1097/01.ftd.0000211804.89440.74DOI
16778713PubMed ID
Keywords:cyclosporine metabolites; pharmacokinetics; bioequivalence; dextromethorphan; phenotyping
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Ute Lange
Deposited On:30 Aug 2007
Last Modified:13 Mar 2014 10:11
Item ID:1972
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