Kees, Frieder and Bucher, Michael and Schweda, Frank and Gschaidmeier, Harald and Burhenne, Juergen and Mikus, Gerd and Faerber, Lothar (2006) Comparative bioavailability of the microemulsion formulation of cyclosporine (Neoral) with a generic dispersion formulation (Cicloral) in young healthy male volunteers. Therapeutic drug monitoring 28 (3), pp. 312-320.
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The aim of this study was to compare the bioavailability of cyclosporine (CyA) from the generic dispersion formulation Cicloral (CIC) with the microemulsion formulation Neoral (NEO) and the original Sandimmune (SIM) capsules after single doses of 100, 300, or 600 mg of drug, respectively. The study was performed according to an open 3-period cross-over design with 12 young healthy male volunteers ...
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|Institutions:||Medicine > Lehrstuhl für Anästhesiologie|
Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
|Keywords:||cyclosporine metabolites; pharmacokinetics; bioequivalence; dextromethorphan; phenotyping|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||30 Aug 2007|
|Last Modified:||13 Mar 2014 10:11|