Höchli, D. and Riemann, D. and Zulley, Jürgen and Berger, M.
Is there a relationship between response to total sleep deprivation and efficacy of clomipramine treatment in depressed patients?
Acta psychiatrica Scandinavica 74 (2), pp. 190-192.
Total sleep deprivation (TSD) and tricyclic medication are successful treatment modalities for patients with a major depressive disorder. Recent studies have suggested a positive relationship between TSD response and succeeding tricyclic treatment, even on a very specific level, thus supporting the assumption of two distinct biochemical subtypes of depression. The present study tested this hypothesis by treating 10 inpatients with a major depressive disorder first with TSD and succeedingly with clomipramine. Contrary to expectation, a negative relationship between clinical response to the two treatment modalities was found.
|Institutions:|| Medicine > Lehrstuhl für Psychiatrie und Psychotherapie|
|Bipolar Disorder/drug therapy||MESH|
|Psychiatric Status Rating Scales||MESH|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||25 Feb 2011 12:51|
|Last Modified:||21 Jul 2011 02:07|