Wiegand, M. and Berger, M. and Zulley, Jürgen and von Zerssen, D.
The Effect of Trimipramine on Sleep in Patients with Major Depressive Disorder.
Pharmacopsychiatry 19 (4), pp. 198-199.
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Antidepressants generally inhibit REM sleep. This effect is
often considered to be a crucial feature of these drugs.
Trimipramine, however, is a tricyclic antidepressant which
does not inhibit REM sleep in rats (Khazan and Brown,
1970; Wassennan and Khazan, 1971). This result could be
confirmed in man: Dunleavy et al. (1972) administered this
drug to two healthy volunteers and found no ...
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