Mader, Heike S. and Link, Martin and Achatz, Daniela E. and Uhlmann, Katrin and Li, Xiaohua and Wolfbeis, Otto S. (2010) Surface-Modified Upconverting Microparticles and Nanoparticles for Use in Click Chemistries. Chemistry: a European journal 16 (18), pp. 5416-5424.
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A method is described for modifying the surface of upconverting microparticles (UCμPs) and nanoparticles (UCNPs) such that they become amenable to click chemistry. Respective reagents are presented and used in both kinds of particles, either directly or in combination with tetraethoxysilane. The particles also were labeled by using the click reaction, a) with fluorophores to yield materials that have emission colors that depend on the wavelength of excitation; b) with maleinimido groups (so to obtain labels for thiols), and c) with biotin (to make them useful for affinity studies based on the biotin–streptavidin system). We believe that both the UCμPs and UCNPs have the potential of being used in numerous areas including upconversion imaging, biolabeling, and derivatization, but also in encoding and security.
|Date:||10 May 2010|
|Institutions:||Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Chemo- und Biosensorik (Prof. Otto S. Wolfbeis)|
|Keywords:||biotin; click chemistry; fluorescence; nanoparticles; upconversion|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||18 Mar 2011 06:50|
|Last Modified:||21 Jul 2011 02:08|