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Molecular tools for the NPY Y1 receptor: Dimerization probes, vesicles, catalytically active derivatives and irreversible ligands

URN to cite this document: urn:nbn:de:bvb:355-epub-199981

Weiß, Stefan (2012) Molecular tools for the NPY Y1 receptor: Dimerization probes, vesicles, catalytically active derivatives and irreversible ligands. PhD, Universität Regensburg

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Abstract (English)

In this thesis antagonists for the neuropeptide Y1 receptor were synthesized. The goal was to modify the known Y1 receptor antagonist BIBP 3266 with different substituents to obtain an insight in structure and functionality of the receptor. Therefore the stability and the affinity of the diverse substituted BIBP 3226 derivatives was investigated in the first chapter. The result was that the Y1 ...

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Translation of the abstract (German)

In dieser Arbeit wurden Antagonisten für den Neuropeptid Y1 Rezeptor synthetisiert. Das Ziel dabei war einen bekannten Antagonisten (BIBP 3226) mit unterschiedlichen Substituenten zu versehen, deren spezielle Eigenschaften einen Einblick in die Struktur und Funktionalität des Rezeptors gewähren sollen. Dazu wurde im ersten Kapitel die Stabilität und Affinität verschiedener substituierter BIBP ...

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Item Type:Thesis of the University of Regensburg (PhD)
Date:6 March 2012
Referee:Prof. Dr. Burkhard König and Prof. Dr. Armin Buschauer
Date of exam:28 February 2011
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Research groups and research centres:Not selected
Keywords:BIBP 3226, neuropeptide Y, acylguanidine, irreversible ligands
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:06 Mar 2012 10:45
Last Modified:13 Mar 2014 18:40
Item ID:19998
Owner Only: item control page

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