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Acyloxybutadiene Iron Tricarbonyl Complexes as Enzyme-Triggered CO-Releasing Molecules (ET-CORMs)

Romanski, Steffen and Kraus, Birgit and Schatzschneider, Ulrich and Neudörfl, Jörg-Martin and Amslinger, Sabine and Schmalz, Hans-Günther (2011) Acyloxybutadiene Iron Tricarbonyl Complexes as Enzyme-Triggered CO-Releasing Molecules (ET-CORMs). Angew. Chem. Int. Ed. 50 (10), pp. 2392-2396.

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Other URL: http://dx.doi.org/10.1002/anie.201006598


Abstract

Molecular hazardous materials transport: Enzyme-triggered CO-releasing molecules (ET-CORMs) offer new options for the delivery of CO. The cleavage of dienylester iron tricarbonyl complexes by an esterase under mild oxidative conditions generates CO, which causes a strong inhibiting activity of the compounds to inducible nitric oxide synthase as shown in a cellular ...

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Item Type:Article
Date:2011
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger
Identification Number:
ValueType
10.1002/anie.201006598DOI
Keywords:carbonyl ligands CO release drug delivery enzyme catalysis inhibitors
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Dr. Sabine Amslinger
Deposited On:10 Mar 2011 07:01
Last Modified:10 Mar 2011 10:00
Item ID:20071
Owner Only: item control page
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