Deutsch
Romanski, Steffen and Kraus, Birgit and Schatzschneider, Ulrich and Neudörfl, Jörg-Martin and Amslinger, Sabine and Schmalz, Hans-Günther (2011) Acyloxybutadiene Iron Tricarbonyl Complexes as Enzyme-Triggered CO-Releasing Molecules (ET-CORMs). Angew. Chem. Int. Ed. 50 (10), pp. 2392-2396.
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Other URL: http://dx.doi.org/10.1002/anie.201006598
Abstract
Molecular hazardous materials transport: Enzyme-triggered CO-releasing molecules (ET-CORMs) offer new options for the delivery of CO. The cleavage of dienylester iron tricarbonyl complexes by an esterase under mild oxidative conditions generates CO, which causes a strong inhibiting activity of the compounds to inducible nitric oxide synthase as shown in a cellular assay.
| Item Type: | Article | ||||
|---|---|---|---|---|---|
| Institutions: | Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger | ||||
| Identification Number: |
| ||||
| Keywords: | carbonyl ligands CO release drug delivery enzyme catalysis inhibitors | ||||
| Subjects: | 500 Science > 540 Chemistry & allied sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Owner: | Dr. Sabine Amslinger | ||||
| Deposited On: | 10 Mar 2011 08:01 | ||||
| Last Modified: | 10 Mar 2011 11:00 | ||||
| Item ID: | 20071 |
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