Amslinger, Sabine (2010) The Tunable Functionality of alpha,beta-Unsaturated Carbonyl Compounds Enables Their Differential Application in Biological Systems. ChemMedChem 5 (3), pp. 351-356.
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alpha,beta-Unsaturated carbonyl compounds as potential drug candidates is a controversial topic since their potential Michael acceptor activity can lead to cell damage and cytotoxicity. Nevertheless, the alpha,beta-unsaturated carbonyl functionality can be employed as a tool to fine tune biological activity by directly manipulating this entity. Depending on their electronic properties, ...
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|Additional Information (public):||568KM Times Cited:1 Cited References Count:46|
|Institutions:||Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger|
|Keywords:||drug design keap1-nrf2 pathway michael addition nf-kappa b alpha,beta-unsaturated carbonyl compounds nitric-oxide production factor-kappa-b tyrosine kinase electrophilic reactivity irreversible inhibitors hepatocyte toxicity antitumor-activity heme oxygenase-1 egf receptor alpha|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||10 Mar 2011 07:09|
|Last Modified:||10 Mar 2011 10:10|