Startseite UB

The Tunable Functionality of alpha,beta-Unsaturated Carbonyl Compounds Enables Their Differential Application in Biological Systems

Amslinger, Sabine (2010) The Tunable Functionality of alpha,beta-Unsaturated Carbonyl Compounds Enables Their Differential Application in Biological Systems. ChemMedChem 5 (3), pp. 351-356.

Full text not available from this repository.

at Web of Science

at publisher (via DOI)


Abstract

alpha,beta-Unsaturated carbonyl compounds as potential drug candidates is a controversial topic since their potential Michael acceptor activity can lead to cell damage and cytotoxicity. Nevertheless, the alpha,beta-unsaturated carbonyl functionality can be employed as a tool to fine tune biological activity by directly manipulating this entity. Depending on their electronic properties, ...

plus


Export bibliographical data

Item Type:Article
Date:2010
Additional information (public):568KM Times Cited:1 Cited References Count:46
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger
Identification Number:
ValueType
000275521200002Web of Science ID
10.1002/cmdc.200900499DOI
Keywords:drug design keap1-nrf2 pathway michael addition nf-kappa b alpha,beta-unsaturated carbonyl compounds nitric-oxide production factor-kappa-b tyrosine kinase electrophilic reactivity irreversible inhibitors hepatocyte toxicity antitumor-activity heme oxygenase-1 egf receptor alpha
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Dr. Sabine Amslinger
Deposited On:10 Mar 2011 07:09
Last Modified:10 Mar 2011 10:10
Item ID:20072
Owner Only: item control page
  1. University

University Library

Publication Server

Contact person
Gernot Deinzer

Telefon 0941 943-2759
Contact