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Perioperative moxifloxacin treatment in rats subjected to deep hypothermic circulatory arrest: reduction in cerebral inflammation but without improvement in cognitive performance

Kellermann, K. and Dertinger, N. and Blobner, M. and Kees, Frieder and Kochs, E. F. and Jungwirt, B. (2011) Perioperative moxifloxacin treatment in rats subjected to deep hypothermic circulatory arrest: reduction in cerebral inflammation but without improvement in cognitive performance. Journal of Thoracic and Cardiovascular Surgery 141 (3), pp. 796-802.

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Abstract

OBJECTIVE: Moxifloxacin reduces infectious complications after cerebral damage, such as ischemia and stroke. This study investigated whether moxifloxacin treatment influences cerebral inflammation and improves cognitive outcome after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats. METHODS: Rats were randomly assigned to deep hypothermic circulatory arrest (n = 40), ...

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Item Type:Article
Date:March 2011
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann formerly Prof. Seifert)
Identification Number:
ValueType
20566208PubMed ID
Subjects:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Rita Prenzyna
Deposited On:29 Mar 2011 04:54
Last Modified:04 Apr 2013 11:35
Item ID:20192
Owner Only: item control page
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