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Identification of wild-type and mutant p53 peptides binding to HLA-A2 assessed by a peptide loading-deficient cell line assay and a novel major histocompatibility complex class I peptide binding assay

Stuber, G. and Leder, G. H. and Storkus, W. T. and Lotze, M. T. and Modrow, Susanne and Székely, L. and Wolf, Hans J. and Klein, E. and Kärre, K. and Klein, G. (1994) Identification of wild-type and mutant p53 peptides binding to HLA-A2 assessed by a peptide loading-deficient cell line assay and a novel major histocompatibility complex class I peptide binding assay. European journal of immunology 24 (3), pp. 765-768.

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Abstract

Mutations of the p53 gene are the most frequently observed genetic changes in human cancers; often leading to an overexpression of the wild-type (wt) p53 protein. Demonstrable T cell reactivity against tumor cells overexpressing wt or mutant p53-derived peptides could support the application of such epitopes in cancer immunotherapies. As the binding of peptide to MHC class I molecules is a ...

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Item Type:Article
Date:1994
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Identification Number:
ValueType
8125143PubMed ID
10.1002/eji.1830240341DOI
Classification:
NotationType
Amino Acid SequenceMESH
Cell LineMESH
HLA-A2 Antigen/immunologyMESH
HumansMESH
Molecular Sequence DataMESH
Peptides/immunologyMESH
Protein BindingMESH
Structure-Activity RelationshipMESH
Tumor Suppressor Protein p53/immunologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:06 Apr 2011 07:44
Last Modified:13 Mar 2014 17:10
Item ID:20395
Owner Only: item control page
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