Deutsch
URN to cite this document: urn:nbn:de:bvb:355-epub-204026
Florian, Christian (2011) Die Rolle Langerin+ Zellen für die Induktion einer humoralen Immunantwort gegen Leishmania major. PhD, Universität Regensburg
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Abstract (German)
Residente T-Zellen in Lymphknoten werden kurz nach der subkutanen Infektion mit Leishmanien aktiviert und beginnen zu proliferieren in drainierenden Lymphknoten von C57BL/6 Mäusen. Katakai et. al. postulierten 2004, dass diese Aktivierung von T-Zellen eventuell in distinkten "immunologischen Plattformen" an der Grenze zwischen B-Zellfollikel und T-Zellbereich stattfindet. Bisher konnte eine solche Plattform in einer T-Zell-vermittelten Immunantwort gegen einen intrazellulären Erreger nicht dargestellt werden. In meiner Dissertation konnte ich zeigen, dass die Aktivierung von CD4+ T-Zellen im "cortical ridge" stattfindet.
Follikuläre T-Zellen sind für eine erfolgreiche humorale Immunantwort notwendig. In meiner Dissertation konnte ich zeigen, dass Langerin+ Zellen aus der Haut für die Induktion von follikulären T-Zellen verantwortlich sind.
Translation of the abstract (English)
Lymph node resident T cells are activated and start to proliferate within skin draining-lymph nodes (SDLNs) of C57BL/6 mice priming early after subcutaneous infection with Leishmania parasites. Katakai et al. postulated in 2004 that T cell priming might take place inside distinct “immunological platforms” located at the interface of the B cell follicle and T cell area. However, the existence of such a distinct micro-compartment in T cell mediated immunity against intracellular parasites has not been described so far. In my thesis I could show that priming of CD4+ T cells occur within the cortical ridge.
Follicular T cells are necessary to maintain a successful humoral immuneresponse. In my thesis I could show that Langerin+ cells from skin a responsible for the induction of follicular T cells.
| Item Type: | Thesis of the University of Regensburg (PhD) |
|---|---|
| Referee: | Prof. Dr. Karl Kunzelmann and PD Dr. Uwe Ritter |
| Date of exam: | 24 March 2011 |
| Institutions: | Biology, Preclinical Medicine > Institut für Physiologie Biology, Preclinical Medicine |
| Interdisciplinary subject network: | Not selected |
| Keywords: | follikuläre T-Zellen, cortical ridge, B-Zellen |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Status: | Published |
| Refereed: | Yes, this version has been refereed |
| Created at the University of Regensburg: | Yes |
| Owner: | Universitätsbibliothek Regensburg |
| Deposited On: | 08 Apr 2011 07:41 |
| Last Modified: | 21 Jul 2011 04:10 |
| Item ID: | 20402 |
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