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Application of the guanidine – acylguanidine bioisosteric approach to argininamide-type NPY Y2 receptor antagonists

Pluym, Nikola and Brennauer, Albert and Keller, Max and Ziemek, Ralf and Pop, Nathalie and Bernhardt, Günther and Buschauer, Armin (2011) Application of the guanidine – acylguanidine bioisosteric approach to argininamide-type NPY Y2 receptor antagonists. ChemMedChem 6 (9), pp. 1727-1738.

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Abstract

Strongly basic groups such as guanidine moieties are crucial structural elements but compromising drug-likeness of numerous biologically active compounds including ligands of G-protein coupled receptors (GPCRs). As part of a project focusing on the search for guanidine bioisosteres, argininamide-type neuropeptide Y (NPY) Y2 receptor (Y2R) antagonists related to BIIE0246 were synthesized. Starting ...

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Item Type:Article
Date:20 June 2011
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1002/cmdc.201100241DOI
21692185PubMed ID
Related URLs:
URLURL Type
http://dx.doi.org/10.1002/cmdc.201100241Publisher
http://onlinelibrary.wiley.com/doi/10.1002/cmdc.201100241/suppinfoSupplementary Material
Keywords:neuropeptide Y; NPY; Y2 receptor; bioisosterism; acylguanidine; argininamide
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:19 May 2011 09:47
Last Modified:26 Aug 2011 13:15
Item ID:20420
Owner Only: item control page
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