Voltz, R. and Jilg, Wolfgang and Wolf, Hans J.
Modification of HLA expression as a possible factor in the pathogenesis of Burkitt's lymphoma.
In: Neth, Rolf, (ed.)
Modern trends in human leukemia VIII : new results in clinical and biological research including pediatric oncology.
Haematology and blood transfusion, 32.
ISBN 3-540-50967-4, 0-387-50967-4.
Our data show that: Most BL cells express significantly less HLA class I and II than the corresponding LCLs. Lymphoblastoid cell lines have a much higher HLA class I and II density than normal peripheral blood B cells. There are qualitative differences in class I and II expression in most BL/LCL pairs. These qualitative differences are not caused by EBV infection. They might be due to a selective downregulation of HLA specifities by c-myc activation. We conclude that these modifications of HLA expression may well play a role in the reduced specific immune recognition of Burkitt's lymphoma cells.
|Item Type:||Book Section|
|Institutions:|| Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene|
|Cell Line, Transformed||MESH|
|Herpesvirus 4, Human||MESH|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Created at the University of Regensburg:||Yes|
|Deposited On:||18 Apr 2011 11:31|
|Last Modified:||21 Jul 2011 02:11|