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Use of synthetic oligopeptides in identification and characterization of immunological functions in the amino acid sequence of the envelope protein of HIV-1

Modrow, Susanne and Höflacher, B. and Mellert, W. and Erfle, V. and Wahren, B. and Wolf, Hans J. (1989) Use of synthetic oligopeptides in identification and characterization of immunological functions in the amino acid sequence of the envelope protein of HIV-1. Journal of acquired immune deficiency syndromes 2 (1), pp. 21-27.

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Abstract

Following computer-assisted analysis of the amino acid sequence of various HIV-1 isolates, we synthesized a series of oligopeptides derived from variable and conserved regions of the envelope protein complex gp120/gp41. The peptides were used in ELISA tests for their reactivity with human antisera from HIV-1 positive individuals; patients with clinically manifested AIDS showed only a rather ...

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Item Type:Article
Date:1989
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Identification Number:
ValueType
2537398PubMed ID
Classification:
NotationType
Acquired Immunodeficiency Syndrome/immunologyMESH
Amino Acid SequenceMESH
AnimalsMESH
Enzyme-Linked Immunosorbent AssayMESH
HIV Antigens/immunologyMESH
HIV Envelope Protein gp120MESH
HIV Envelope Protein gp41MESH
HIV-1/immunologyMESH
HumansMESH
Lymphocyte ActivationMESH
Oligopeptides/diagnostic useMESH
RabbitsMESH
Retroviridae Proteins/immunologyMESH
Viral Envelope Proteins/immunologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:18 Apr 2011 11:32
Last Modified:13 Mar 2014 17:16
Item ID:20521
Owner Only: item control page
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