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Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS

Starcich, B. R. and Hahn, B. H. and Shaw, G.M. and McNeely, P. D. and Modrow, Susanne and Wolf, Hans J. and Parks, E. S. and Parks, W. P. and Josephs, S. F. and Gallo, R. C. (1986) Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS. Cell 45 (5), pp. 637-648.

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Abstract

To determine the extent and nature of genetic variation present in independent isolates of HTLV-III/LAV, the nucleotide sequences of the entire envelope gene and parts of gag and pol were determined for two AIDS viruses. The results indicated that variation throughout the viral genome is extensive and that the envelope gene in particular is most highly variable. Within the envelope, changes were ...

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Item Type:Article
Date:1986
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Identification Number:
ValueType
2423250PubMed ID
10.1016/0092-8674(86)90778-6DOI
Classification:
NotationType
Acquired Immunodeficiency Syndrome/microbiologyMESH
Amino Acid SequenceMESH
Base SequenceMESH
Deltaretrovirus/isolation & purificationMESH
Gene Products, gagMESH
Genes, ViralMESH
Genetic VariationMESH
Nucleic Acid ConformationMESH
RNA-Directed DNA Polymerase/geneticsMESH
Retroviridae Proteins/geneticsMESH
Sequence Homology, Nucleic AcidMESH
Viral Envelope Proteins/geneticsMESH
Viral Proteins/geneticsMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Apr 2011 12:42
Last Modified:13 Mar 2014 17:17
Item ID:20553
Owner Only: item control page
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