Brunskole, Irena and Strasser, Andrea and Seifert, Roland and Buschauer, Armin (2011) Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation. Naunyn-Schmiedeberg's Archives of Pharmacology 384 (3), pp. 301-317.
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The histamine H4 receptor subtype (H4R) belongs to the class 1 of G protein-coupled receptors and is involved in inflammatory and immunological processes. The aim of this study was to elucidate the importance of extracellular regions for the large species differences between human (h) and canine (c) H4R. Therefore, chimeric receptors were generated by replacing corresponding domains of the hH4R ...
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|Date:||29 July 2011|
|Institutions:||Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)|
|Projects:||GRK 760, Graduiertenkolleg Medizinische Chemie|
|Keywords:||histamine H4 receptor, Sf9 insect cells, chimeric receptors, extracellular loops, steady-state GTPase assay, JNJ7777120|
|Subjects:||500 Science > 570 Life sciences|
500 Science > 540 Chemistry & allied sciences
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||15 Jul 2011 07:15|
|Last Modified:||19 Aug 2011 18:39|