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Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation

Brunskole, Irena and Strasser, Andrea and Seifert, Roland and Buschauer, Armin (2011) Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation. Naunyn-Schmiedeberg's Archives of Pharmacology 384 (3), pp. 301-317.

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Abstract

The histamine H4 receptor subtype (H4R) belongs to the class 1 of G protein-coupled receptors and is involved in inflammatory and immunological processes. The aim of this study was to elucidate the importance of extracellular regions for the large species differences between human (h) and canine (c) H4R. Therefore, chimeric receptors were generated by replacing corresponding domains of the hH4R ...

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Item Type:Article
Date:29 July 2011
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1007/s00210-011-0673-3DOI
21800093PubMed ID
Keywords:histamine H4 receptor, Sf9 insect cells, chimeric receptors, extracellular loops, steady-state GTPase assay, JNJ7777120
Subjects:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Prof. Armin Buschauer
Deposited On:15 Jul 2011 07:15
Last Modified:19 Aug 2011 18:39
Item ID:20716
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