Seitz, Tobias and Thoma, Ralf and Schoch, Guillaume A. and Stihle, Martine and Benz, Jörg and D'Arcy, Brigitte and Wiget, Andrea and Ruf, Armin and Hennig, Michael and Sterner, Reinhard (2010) Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening. Journal of molecular biology 403 (4), pp. 562-577.
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The human glucocorticoid receptor ligand-binding domain (hGR-LBD) is an important drug target for the treatment of various diseases. However, the low intrinsic stability and solubility of hGR-LBD have rendered its purification and biophysical characterization difficult. In order to overcome these problems, we have stabilized hGR-LBD by a combination of random mutagenesis and high-throughput ...
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|Institutions:||Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Reinhard Sterner|
|Dewey Decimal Classification:||500 Science > 570 Life sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||03 May 2011 06:01|
|Last Modified:||03 May 2011 06:01|