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Pulmonary distribution and efficacy of exogenous surfactant in lung-lavaged rabbits are influenced by the instillation technique

Segerer, Hugo and van Gelder, W. and Angenent, F. W. and van Woerkens, L. J. and Curstedt, T. and Obladen, M. and Lachmann, B. (1993) Pulmonary distribution and efficacy of exogenous surfactant in lung-lavaged rabbits are influenced by the instillation technique. Pediatric research 34 (4), pp. 490-494.

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Abstract

Surfactant bolus instillation has been reported to cause changes in arterial blood pressure (BP) and cerebral blood flow velocities which may increase the risk of intraventricular haemorrhage. To avoid these effects, slow tracheal infusion was evaluated as a possible alternative method of surfactant administration. Saline lung lavages were performed in 13 anesthetized and artificially ventilated ...

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Item Type:Article
Date:1993
Institutions:Medicine > Lehrstuhl für Kinder- und Jugendmedizin
Identification Number:
ValueType
8255683PubMed ID
Classification:
NotationType
1,2-Dipalmitoylphosphatidylcholine/pharmacokineticsMESH
AnimalsMESH
Biological ProductsMESH
Carbon RadioisotopesMESH
Instillation, DrugMESH
Lung/physiologyMESH
MaleMESH
MicrospheresMESH
PhospholipidsMESH
Positive-Pressure RespirationMESH
Pulmonary Surfactants/pharmacokineticsMESH
RabbitsMESH
SystoleMESH
Therapeutic IrrigationMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Unknown
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:10 May 2011 08:36
Last Modified:13 Mar 2014 17:21
Item ID:20802
Owner Only: item control page
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