Stevens, P. A. and Schadow, B. and Bartholain, S. and Segerer, Hugo and Obladen, Michael
Surfactant protein A in the course of respiratory distress syndrome.
European journal of pediatrics 151 (8), pp. 596-600.
Surfactant-associated protein (SP-A) was measured in tracheal aspirates of ventilated infants with (n = 51) and without (n = 21) respiratory distress syndrome (RDS). SP-A concentrations in samples collected after birth were significantly lower in RDS than in infants ventilated for other reasons than RDS (median 0.03 vs. 1.60 micrograms/ml). As a biochemical test to diagnose RDS early after birth, the sensitivity of measuring SP-A in tracheal aspirates was 87% and specificity 81%. SP-A content in tracheal aspirates of infants with RDS was monitored during the first 7 days of life. A significant (P less than 0.001) increase within the first 4 days was found in those infants who survived, whereas no such change was found in those infants who died.
|Institutions:|| Medicine > Lehrstuhl für Kinder- und Jugendmedizin|
|Enzyme-Linked Immunosorbent Assay||MESH|
|Pulmonary Surfactant-Associated Protein A||MESH|
|Pulmonary Surfactant-Associated Proteins||MESH|
|Respiratory Distress Syndrome, Newborn/metabolism||MESH|
|Sensitivity and Specificity||MESH|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||16 May 2011 12:56|
|Last Modified:||21 Jul 2011 02:13|