Bohles, H. and Segerer, Hugo and Fekl, W.
Improved N-retention during L-carnitine-supplemented total parenteral nutrition.
Journal of parenteral and enteral nutrition : JPEN 8 (1), pp. 9-13.
The influence of intravenously administered L-carnitine on lipid- and nitrogen-metabolism was studied during total parenteral nutrition of piglets (mean weight 4077 g; n = 9). The infusion protocol was divided into three isocaloric and isonitrogenous 48-hr periods. Amino acids (3 g/kg day) were administered throughout all three periods: 140 cal/kg/day were given as nonprotein calories, consisting only of glucose during period 1; during periods 2 and 3, an amount of glucose calorically equivalent to 4 g fat/kg/day was substituted with a lipid emulsion, and L-carnitine (1.5 mg/kg/day) was added in period 3. Key parameters of fat- and nitrogen-metabolism were determined during the entire regime. Indirect calorimetry was performed and the respiratory quotient calculated during all three periods. The results demonstrate a more effective lipolysis and oxidation of fatty acids during L-carnitine supplementation. These changes produce an increased energy gain from exogenously administered fat and a distinct improvement in nitrogen balance.
|Additional information (public):||Rechteübertragung 1966 – 1994|
|Institutions:|| Medicine > Lehrstuhl für Kinder- und Jugendmedizin|
|Amino Acids/administration & dosage||MESH|
|Fat Emulsions, Intravenous/administration & dosage||MESH|
|Glucose/administration & dosage||MESH|
|Parenteral Nutrition, Total||MESH|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||18 May 2011 08:50|
|Last Modified:||21 Jul 2011 02:13|