Böhles, H. and Segerer, Hugo and Fekl, W. and Stehr, K. (1983) Tierexperimentelle Untersuchungen über Veränderungen des Lipid- und Proteinstoffwechsels bei L-Carnitin-supplementierter totaler parenteraler Ernährung = Animal experiment studies on the changes in lipid and protein metabolism in L-carnitine-supplemented total parenteral nutrition. Infusionstherapie und klinische Ernährung 10 (1), pp. 24-31.
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The influence of i.v. L-carnitine on parameters of lipid- and nitrogen metabolism was studied during total parenteral nutrition of mini pigs (x: 4077; n = 9). The infusion protocol was divided into isocaloric and isonitrogenous 48-hour-periods. Amino acids (3 g/kg/day) were administered throughout all three periods. 140 Cal/kg/day were given as non-protein calories, consisting only of glucose during period 1. During periods 2 and 3 an amount of glucose calorically equivalent to 4 g fat/kg/day was substituted with a lipid emulsion. In period 3, L-carnitine (1,5 mg/kg/day) was added. During the entire regime key parameters of fat and nitrogen metabolism were determined. During all three periods indirect calorimetry was performed and the respiratory quotient calculated. The results demonstrate a more effective lipolysis and oxydation of fatty acids during L-carnitine supplementation. This results in an increased energy gain from exogenously administered fat and a distinct improvement of nitrogen balance.
|Institutions:||Medicine > Lehrstuhl für Kinder- und Jugendmedizin|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||10 Jun 2011 10:58|
|Last Modified:||10 Jun 2011 10:58|