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Reinigung und funktionelle Charakterisierung eines rekombinanten Maus-TNF-Inhibitors

URN to cite this document: urn:nbn:de:bvb:355-epub-210749

Pausch, Markus J. (2011) Reinigung und funktionelle Charakterisierung eines rekombinanten Maus-TNF-Inhibitors. PhD, Universität Regensburg

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Abstract (German)

TNF und seine Rezeptoren p75TNFR und p55TNFR spielen im Rahmen von Entzündungen und Autoimmunerkrankungen eine zentrale Rolle. Eine gezielte Hemmung von TNF wird bei Autoimmunerkrankungen, wie z.B. rheumatoider Arthritis eingesetzt. In der Arbeit wurde ein rekombinanter TNF-Inhibitor hergestellt, sowie dessen Struktur und biologische Wirksamkeit untersucht.

Translation of the abstract (English)

TNF and its receptors p75TNFR and p55TNFR play a central role in the context of inflammation and autoimmune diseases. A targeted inhibition of TNF is used in autoimmune diseases such as rheumatoid arthritis. In this study a recombinant TNF-inhibitor was prepared and its structure and biological activity examined.

Item Type:	Thesis of the University of Regensburg (PhD)
Referee:	Prof. Dr. Daniela N. Männel and Prof. Dr. Bernd Salzberger
Date of exam:	27 May 2011
Institutions:	Medicine > Lehrstuhl für Immunologie
Keywords:	Entzündung, Autoimmunerkrankung, p75TNFR, TNF, maus-TNF-Inhibitor, anti-TNF-Medikation, Biologicals, inflammation, autoimmune disease, p75TNFR, TNF, mouse-TNF-Inhibitor, anti-TNF-Medication, Biologicals
Subjects:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Owner:	Universitätsbibliothek Regensburg
Deposited On:	15 Jun 2011 08:28
Last Modified:	21 Jul 2011 04:14
Item ID:	21074

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