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Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2)

Ochoa Puentes, Cristian and Höcherl, Peter and Kühnle, Matthias and Bauer, Stefanie and Kürger, Kira and Bernhardt, Günther and Buschauer, Armin and König, Burkhard (2011) Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2). Bioorganic & Medicinal Chemistry Letters 21 (12), pp. 3654-3657.

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Abstract

Aiming at structural optimization of potent and selective ABCG2 inhibitors, such as UR-ME22-1, from our laboratory, an efficient solid phase synthesis was developed to get convenient access to this class of compounds. 7-Carboxyisatoic anhydride was attached to Wang resin to give resin bound 2-aminoterephthalic acid. Acylation with quinoline-2- or -6-carbonyl chlorides, coupling with ...

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Item Type:Article
Date:2011
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
ValueType
10.1016/j.bmcl.2011.04.094DOI
21570282PubMed ID
Keywords:Tariquidar, ABCB1, ABCG2, Hoechst 33342, Wang resin
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Regina Hoheisel
Deposited On:03 Jun 2011 10:14
Last Modified:03 Jun 2011 10:14
Item ID:21098
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