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T cells migrate to tumour sites after extracorporeal interleukin 2 stimulation and reinfusion in a patient with metastatic melanoma

Dummer, R. and Becker, J. C. and Eilles, Christoph and Schäfer, E. and Börner, W. and Burg, G. (1993) T cells migrate to tumour sites after extracorporeal interleukin 2 stimulation and reinfusion in a patient with metastatic melanoma. The British journal of dermatology 128 (4), pp. 399-403.

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Abstract

Peripheral blood mononuclear cells (PBMC) were taken by leukapheresis from a patient with melanoma skin metastases and stimulated in vitro using 1000 IU recombinant interleukin 2 (IL-2)/ml to generate lymphokine-activated killer cells (LAK cells). Two-colour immunofluorescence analysis demonstrated an IL-2-induced up-regulation of CD25 on natural killer cells (CD56+) as well as on T lymphocytes ...

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Item Type:Article
Date:1993
Institutions:Medicine > Abteilung für Nuklearmedizin
Identification Number:
ValueType
8494752PubMed ID
Classification:
NotationType
Cell MovementMESH
Cytotoxicity, ImmunologicMESH
HumansMESH
Interleukin-2/pharmacologyMESH
Killer Cells, Lymphokine-Activated/transplantationMESH
Killer Cells, Natural/immunologyMESH
Leukocyte CountMESH
Lymphocyte ActivationMESH
MaleMESH
Melanoma/pathologyMESH
Middle AgedMESH
Receptors, Interleukin-2/immunologyMESH
Recombinant Proteins/pharmacologyMESH
Skin Neoplasms/secondaryMESH
T-Lymphocyte Subsets/immunologyMESH
Up-RegulationMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:10 Jun 2011 07:48
Last Modified:13 Mar 2014 17:32
Item ID:21111
Owner Only: item control page
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