Reiners, C. and Reimann, J. and Schäffer, R. and Baum, K. and Becker, W. and Eilles, Christoph and Gerhards, W. and Schick, F. and Spiegel, W. and Wiedemann, W.
Das metastasierende differenzierte Schilddrüsenkarzinom. Diagnostische Treffsicherheit des Thyreoglobulin-RIA im Vergleich zur 13'J-Ganzkörperszintigraphie = Metastatic differentiated thyroid cancer. Diagnostic accuracy of thyroglobulin-RIA in comparison with 131I-whole body scintigraphy.
RöFo: Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin 141 (3), pp. 306-313.
In a retrospective analysis in patients with differentiated thyroid carcinoma, the diagnostic validities of 131I whole-body scans and radioimmunologic determinations of thyroglobulin (hTg) are compared with special regard to late metastases. Metastases were found in 83 out of 311 patients with differentiated thyroid carcinoma. In two thirds of the cases, these were primary metastases while in the remaining third of the cases, metastases developed in later follow-up with a mean time of latency of 3.3 years. While about 70% of the early metastases could bei detected by 131I scintigraphy, this percentage amounted to only 40% in late metastases. With a diagnostic sensitivity of 90%, hTg-RIA was clearly superior in the detection of early as well as of late metastases. hTg was measurable, however, only in iatrogenous hypothyroidism in 4 out of 49 cases. Based on these results and an analysis of the literature, a program for follow-up of differentiated thyroid carcinoma is proposed. The hTg-RIA is thereby used as an alternative to 131I scintigraphy in the late phase of follow-up after complete ablation of any thyroid tissue.
|Institutions:|| Medicine > Abteilung für Nuklearmedizin|
|Carcinoma, Papillary/radionuclide imaging||MESH|
|Iodine Radioisotopes/diagnostic use||MESH|
|Neoplasm Metastasis/radionuclide imaging||MESH|
|Thyroid Neoplasms/radionuclide imaging||MESH|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||10 Jun 2011 07:32|
|Last Modified:||21 Jul 2011 02:14|