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A common epitope on human tumor necrosis factor alpha and the autoantigen 'S-antigen/arrestin' induces TNF-alpha production

Stiemer, R. H. and Westenfelder, U. and Gausepohl, H. and Mirshahi, M. and Gundt, A. and Frank, R. W. and Männel, Daniela N. (1992) A common epitope on human tumor necrosis factor alpha and the autoantigen 'S-antigen/arrestin' induces TNF-alpha production. Journal of autoimmunity 5 (1), pp. 15-26.

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Abstract

A common epitope on S-antigen (arrestin), a potent autoantigen inducing experimental autoimmune uveoretinitis (EAU), and on human tumor necrosis factor alpha (hTNF alpha) was revealed using two monoclonal antibodies to S-antigen which inhibit EAU induction. The minimal common sequence for monoclonal antibody recognition is GVxLxD in the S-antigen/hTNF alpha amino acid sequences. Peptides ...

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Item Type:Article
Date:1992
Institutions:Medicine > Lehrstuhl für Immunologie
Identification Number:
ValueType
1373060PubMed ID
Classification:
NotationType
Amino Acid SequenceMESH
AnimalsMESH
Antibodies, MonoclonalMESH
Antigens/immunologyMESH
ArrestinMESH
Autoantigens/immunologyMESH
CattleMESH
Epitopes/immunologyMESH
Eye Proteins/immunologyMESH
HumansMESH
ImmunoblottingMESH
MiceMESH
Molecular Sequence DataMESH
Peptides/immunologyMESH
Phosphodiesterase Inhibitors/immunologyMESH
Retinitis/immunologyMESH
Sequence Homology, Nucleic AcidMESH
Tumor Necrosis Factor-alpha/immunologyMESH
Uveitis/immunologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:17 Jun 2011 06:06
Last Modified:13 Mar 2014 17:33
Item ID:21161
Owner Only: item control page

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