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Cytokine induction by immunomodulatory epitopes in S-antigen and tumor necrosis factor alpha

Stiemer, R. H. and Westenfelder, U. and de Kozak, Y. and Gausepohl, H. and Mirshahi, M. and Frank, R. W. and Faure, J. P. and Männel, Daniela N. (1992) Cytokine induction by immunomodulatory epitopes in S-antigen and tumor necrosis factor alpha. Current eye research 11 Sup, pp. 197-202.

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Abstract

Common epitopes on S-antigen (arrestin), a potent autoantigen inducing experimental autoimmune uveoretinitis (EAU), and on human tumor necrosis factor alpha (hTNF alpha) are revealed with monoclonal antibodies (mAb) to S-antigen, which inhibit EAU induction. The minimal common sequence for mAb recognition is GVxLxD in the S-antigen/hTNF alpha amino acid (aa) sequences. Peptides containing this ...

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Item Type:Article
Date:1992
Institutions:Medicine > Lehrstuhl für Immunologie
Identification Number:
ValueType
1385043PubMed ID
Classification:
NotationType
Amino Acid SequenceMESH
AnimalsMESH
Antibodies, Anti-Idiotypic/immunologyMESH
Antibodies, MonoclonalMESH
Antigens/immunologyMESH
ArrestinMESH
Autoantigens/immunologyMESH
Cross Reactions/immunologyMESH
Cytokines/immunologyMESH
Epitopes/immunologyMESH
Eye Proteins/immunologyMESH
HumansMESH
Molecular Sequence DataMESH
Monocytes/immunologyMESH
Sequence Homology, Amino AcidMESH
Tumor Necrosis Factor-alpha/immunologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:17 Jun 2011 06:01
Last Modified:13 Mar 2014 17:33
Item ID:21164
Owner Only: item control page
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