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Isoniazid protects mice against endotoxin lethality without influencing tumor necrosis factor synthesis and release

Urbaschek, R. and Männel, Daniela N. and Urbanczik, R. (1991) Isoniazid protects mice against endotoxin lethality without influencing tumor necrosis factor synthesis and release. Antimicrobial agents and chemotherapy 35 (8), pp. 1666-1668.

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Abstract

Treatment of NMRI mice with isoniazid (INH; 25 mg/kg) intraperitoneally induced significant protection when it was injected before or after a lethal intravenous challenge with endotoxin. The INH preparation used was not contaminated with endotoxin. Tumor necrosis factor (TNF) was not elevated in sera from NMRI mice 2 h after the injection of INH. INH did not influence TNF synthesis or release ...

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Item Type:Article
Date:1991
Institutions:Medicine > Lehrstuhl für Immunologie
Identification Number:
ValueType
1929338PubMed ID
Classification:
NotationType
AnimalsMESH
Cells, CulturedMESH
Endotoxins/toxicityMESH
FemaleMESH
HumansMESH
Isoniazid/pharmacologyMESH
MiceMESH
Monocytes/metabolismMESH
RNA, Messenger/metabolismMESH
Tumor Necrosis Factor-alpha/secretionMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:17 Jun 2011 05:59
Last Modified:13 Mar 2014 17:33
Item ID:21166
Owner Only: item control page

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