Urbaschek, R. and Männel, Daniela N. and Urbanczik, R.
Isoniazid protects mice against endotoxin lethality without influencing tumor necrosis factor synthesis and release.
Antimicrobial agents and chemotherapy 35 (8), pp. 1666-1668.
Treatment of NMRI mice with isoniazid (INH; 25 mg/kg) intraperitoneally induced significant protection when it was injected before or after a lethal intravenous challenge with endotoxin. The INH preparation used was not contaminated with endotoxin. Tumor necrosis factor (TNF) was not elevated in sera from NMRI mice 2 h after the injection of INH. INH did not influence TNF synthesis or release determined in human monocytes in vitro. Therefore, it is concluded that the protective effect of INH against lethal endotoxin is not due to a suppressive effect of INH on TNF production.
|Institutions:|| Medicine > Lehrstuhl für Immunologie|
|Tumor Necrosis Factor-alpha/secretion||MESH|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||17 Jun 2011 05:59|
|Last Modified:||22 Oct 2012 09:19|