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Regulation of TNF-alpha, IL-1 and IL-6 synthesis in differentiating human monoblastoid leukemic U937 cells

Hass, R. and Lonnemann, G. and Männel, Daniela N. and Topley, N. and Hartmann, A. and Köhler, L. and Resch, K. and Goppelt-Strübe, M. (1991) Regulation of TNF-alpha, IL-1 and IL-6 synthesis in differentiating human monoblastoid leukemic U937 cells. Leukemia research 15 (5), pp. 327-339.

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Abstract

The human monoblastoid tumor cell line U937 was induced to differentiate along the monocyte/macrophage lineage by treatment with 5 x 10(-9) M 12-O-tetradecanoyl phorbol-13-acetate (TPA). Between 2 h and 4 h following TPA-treatment U937 cells started to release significant amounts of TNF-alpha which remained detectable until 8-10 days. A significant IL-1 beta release was measured 24 h-48 h post ...

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Item Type:Article
Date:1991
Institutions:Medicine > Lehrstuhl für Immunologie
Identification Number:
ValueType
1904515PubMed ID
Classification:
NotationType
Blotting, NorthernMESH
Cell Differentiation/drug effectsMESH
Cell LineMESH
Dinoprostone/pharmacologyMESH
HumansMESH
Interferon-gamma, Recombinant/pharmacologyMESH
Interleukin-1/geneticsMESH
Interleukin-6/geneticsMESH
KineticsMESH
Leukemia, Monocytic, AcuteMESH
RNA, Messenger/geneticsMESH
Recombinant Proteins/pharmacologyMESH
Tetradecanoylphorbol Acetate/pharmacologyMESH
Tumor Necrosis Factor-alpha/pharmacologyMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Jun 2011 06:18
Last Modified:13 Mar 2014 17:33
Item ID:21168
Owner Only: item control page

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