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Long-term effects of 2'-deoxycoformycin treatment on cytokine production in patients with hairy cell leukemia

Ho, A. D. and Männel, Daniela N. and Wulf, G. and Kirchner, H. and Gundt, A. and Trede, I. and Rensch, K. and Hunstein, W. (1990) Long-term effects of 2'-deoxycoformycin treatment on cytokine production in patients with hairy cell leukemia. Leukemia 4 (8), pp. 584-589.

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Abstract

Deoxycoformycin (DCF) has been reported to cause immediate reduction and dysfunction of T lymphocytes, but the long-term effects on immune functions are still not known. As cytokine production is regulated by T helper-inducer lymphocytes and might represent a parameter for functional integrity of immunocompetent cells, we have measured the production of interleukin-2 (IL-2), tumor necrosis factor ...

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Item Type:Article
Date:1990
Institutions:Medicine > Lehrstuhl für Immunologie
Identification Number:
ValueType
1697012PubMed ID
Classification:
NotationType
AdultMESH
AgedMESH
FemaleMESH
HumansMESH
Interferons/biosynthesisMESH
Interleukin-2/biosynthesisMESH
Leukemia, Hairy Cell/metabolismMESH
Leukocyte Count/drug effectsMESH
Leukocytes, Mononuclear/metabolismMESH
MaleMESH
Middle AgedMESH
Pentostatin/therapeutic useMESH
Remission InductionMESH
T-Lymphocytes/drug effectsMESH
Time FactorsMESH
Tumor Necrosis Factor-alpha/biosynthesisMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:20 Jun 2011 06:29
Last Modified:22 Oct 2012 09:29
Item ID:21172
Owner Only: item control page
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