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Distinct tumor cell membrane constituents activate human monocytes for tumor necrosis factor synthesis

Jänicke, R. and Männel, Daniela N. (1990) Distinct tumor cell membrane constituents activate human monocytes for tumor necrosis factor synthesis. The Journal of Immunology 144 (3), pp. 1144-1150.

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Abstract

Several lines of evidence point to an activation mechanism of monocytes/macrophages by tumor cells. In this study we present data for distinct surface structures on K562 and Jurkat cells to directly induce TNF-mRNA expression and TNF production by human peripheral blood monocytes. Northern analysis showed that incubation of monocytes with either K562 or Jurkat cells led to a significant increase ...

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Item Type:Article
Date:1990
Institutions:Medicine > Lehrstuhl für Immunologie
Identification Number:
ValueType
2295816PubMed ID
Classification:
NotationType
Blotting, NorthernMESH
Gene Expression RegulationMESH
HumansMESH
Lipopolysaccharides/pharmacologyMESH
Macrophage ActivationMESH
Membrane Proteins/physiologyMESH
Monocytes/metabolismMESH
Neoplasm Proteins/physiologyMESH
Neoplasms/physiopathologyMESH
RNA, Messenger/geneticsMESH
Tumor Cells, CulturedMESH
Tumor Necrosis Factor-alpha/biosynthesisMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:20 Jun 2011 06:20
Last Modified:13 Mar 2014 17:33
Item ID:21173
Owner Only: item control page
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