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Autocrine stimulation of TNF-alpha mRNA expression in HL-60 cells

Hensel, G. and Männel, Daniela N. and Pfizenmaier, K. and Krönke, M. (1987) Autocrine stimulation of TNF-alpha mRNA expression in HL-60 cells. Lymphokine research 6 (2), pp. 119-125.

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Abstract

We have employed a human promyelocytic leukemic cell line, HL-60, to investigate the conditions that regulate TNF-alpha gene expression in vitro. Using a cloned TNF-alpha specific cDNA probe, we show by Northern blot analysis that TNF-alpha mRNA rapidly accumulates in HL-60 cells following treatment with phorbol myristate acetate (PMA). TNF-alpha mRNA levels peak at 1-2 hours and then decline to ...

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Item Type:Article
Date:1987
Institutions:Medicine > Lehrstuhl für Immunologie
Identification Number:
ValueType
3108589PubMed ID
Classification:
NotationType
Cell LineMESH
Gene Expression Regulation/drug effectsMESH
Glycoproteins/pharmacologyMESH
HumansMESH
Interferon Type I/pharmacologyMESH
Interferon-gamma/pharmacologyMESH
Macrophage ActivationMESH
RNA, Messenger/metabolismMESH
Tetradecanoylphorbol Acetate/pharmacologyMESH
Tumor Necrosis Factor-alphaMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Gertraud Kellers
Deposited On:22 Jun 2011 08:16
Last Modified:22 Oct 2012 09:47
Item ID:21189
Owner Only: item control page
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